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Home arrow Health arrow Gut Health arrow Seed Probiotics: Is It Any Good for Gastrointestinal Health?

Seed Probiotics: Is It Any Good for Gastrointestinal Health?

Dr. Donika Vata
Written by Donika Vata, MD
Fact checked by Edna Skopljak, MD
Last update: September 20, 2023
12 min read 1000 Views 3 Reviews
clock 12 eye 1000 comments 3

Could Seed Daily Synbiotic be the answer to better gastrointestinal health? Here’s my detailed review of this dietary supplement, including its pros and cons, to help you make an informed decision.

Seed Probiotics Review - Is It as Good as Expected

How do we vet brands and products? Learn more.

If you’re growing tired of bloating, gas, irregular bowel movements, and other common digestive complaints, you might want to consider taking a probiotic to improve your gut health.

Probiotics, alongside a healthy lifestyle, can work wonders for your gut health. These live bacteria and yeasts promote bacterial balance in your gut, improving digestion and reducing symptoms of digestive disorders.

This is where the Seed Daily Synbiotic comes in. It’s one of the most popular probiotic supplements available in the market, designed to support systemic health. The company claims that it’s made of polyphenol-based prebiotic and scientifically studied probiotic strains.

These claims made me curious about this product, which is why I decided to examine it thoroughly. So, in this Seed probiotic review, I’ll share everything I learned about their DS-01 Daily Synbiotic, including its ingredients, advantages, and drawbacks.

What Are Seed Probiotics?

Seed Logo
Our rating:
  • Promotes digestive health to reduce discomfort
  • Supports immunity and cardiovascular health
Learn More
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    Supports gut immune function
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    Boosts skin health
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    No need to refrigerate
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    Shelf-stable formula
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    Free from allergens
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    No preservatives
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    Unique delivery system to reach the digestive system
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    Sustainable refills
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    Free US shipping
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    Expensive for a 30-day supply compared to other probiotic brands
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    Must commit to a monthly subscription
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    Some users report side effects
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    Not suitable for those under the age of 18

Currently, Seed offers the following 2 Daily Synbiotic supplements:

PDS-08 Pediatric Daily Synbiotic: For teens (3 to 17 years of age)

DS-01 Daily Synbiotic: For adults (18 and above)

In this Seed Probiotic review, I’ll focus on DS-01 Daily Synbiotic, which is a 2-in-1 (prebiotic and probiotic) supplement. The company claims that it’s designed to support the digestive system in adults.

Each capsule of this supplement contains 24 clinically studied active probiotic strains to support the human body. It’s manufactured with a prebiotic outer capsule and probiotic inner capsule to ensure the stomach acid doesn’t destroy probiotics before they make it to the gut.

Other than supporting your gut microbiome, it’s also said that Seed can improve your overall health. The company claims that users can expect better gut function, less digestive discomfort, gut barrier integrity, better skin, and a healthy heart.

I can tell you that it makes sense scientifically because the gut is partly responsible for how your body functions. It means that if a dietary supplement actually supports your gut health, it can lead to improved overall well-being.

⭐ Rating


✅ Who is it for?

Adults (18+)

❌ Side effects

Mild nausea, constipation, diarrhea

💊 Dosage form


🥦 Vegan?


💰 Price

From $49.99/month

🌎 Official Website

How Does the Seed Probiotic Work?

I was impressed by seeing the working mechanism of Seed DS-01. It comes with 2 layers, including:

  • Outer prebiotic capsule
  • Inner probiotic capsule

The outer capsule, containing probiotics, dissolves in the stomach, while the inner one survives the stomach acid and reaches the colon with the live cultures still intact. It allows bacteria to make it to the colon alive to do their job.

A study confirms that the DS-01 capsule (with double-layer technology) can successfully deliver high numbers of probiotics to the gastrointestinal tract without being destroyed by digestive enzymes along the way.

According to the manufacturer, you should start taking 1 capsule daily for the first 3 days and then increase your dosage to 2 capsules daily.

Does Seed Probiotic Work?

Many of the ingredients that Seed DS-01 Daily Synbiotic contains are scientifically proven to improve your gastronomical health. For example, the Lactiplantibacillus plantarum strain, used in the supplement’s digestive health probiotic blend, is known to have beneficial effects against constipation and gastric inflammation.

The manufacturer of Seed DS-01 suggests that you can start noticing gastro-related results within 24–48 hours, such as less bloating and more frequent bowel movements. I’ve also watched some videos and read some reviews from influencers/YouTubers and users saying that they have experienced results even faster.

However, you should keep in mind that every individual is unique and might react differently to probiotics. So, you might notice fast results, gradual results, and in some cases, none at all.

Usually, even the best probiotics take time to do their job. It means that you can expect anywhere from a few weeks to a few months to start experiencing results. So, try to remain patient (and consistent) before giving up on any dietary supplement. In the meantime, remember to look for signs that probiotics are working.

Key Ingredients of Seed Daily Synbiotic

I read on the official Seed website that the formulation of DS-01 contains 53.6 billion AFUs* (Active-fluorescent units) in total. These units are split among different probiotic blends with different strains, including the following.

*AFU is an alternative and more precise method of counting live and active microbes than the CFU (colony-forming unit).

#1 Digestive health probiotic blend

This is the biggest blend in Seed DS-01, as it has 37.0 billion AFUs, and it contains the following strains.

  • Bifidobacterium longum SD-BB536-JP 
  • Bifidobacterium breve SD-BR3-IT 
  • Lactiplantibacillus plantarum SD-LP1-IT 
  • Lacticaseibacillus rhamnosus SD-LR6-IT 
  • Lacticaseibacillus rhamnosus HRVD113-US 
  • Bifidobacterium infantis SD-M63-JP 
  • Bifidobacterium lactis SD-BS5-IT 
  • Bifidobacterium lactis HRVD524-US 
  • Lactobacillus crispatus SD-LCR01-IT 
  • Lacticaseibacillus casei HRVD300-US 
  • Bifidobacterium breve HRVD521-US 
  • Bifidobacterium longum HRVD90b-US 
  • Bifidobacterium lactis SD150-BE 
  • Limosilactobacillus fermentum SD-LF8-IT 
  • Lacticaseibacillus rhamnosus SD-GG-BE 
  • Limosilactobacillus reuteri RD830-FR

#2 Dermatological health probiotic blend

There are 3.30 billion AFUs in this blend, with the following strains:

  • Ligilactobacillus salivarius SD-LS1-IT
  • Bifidobacterium lactis SD-CECT8145-SP
  • Bifidobacterium longum SD-CECT7347-SP
  • Lacticaseibacillus casei SD-CECT9104-SP

#3 Micronutrient synthesis probiotic blend

This blend has 5.25 billion AFUs, containing these strains:

  • Lactiplantibacillus plantarum SD-LPLDL-UK
  • Bifidobacterium lactis SD-MB2409-IT

#4 Cardiovascular health probiotic blend

It has 8.05 billion AFUs, and the strains it contains are:

  • Bifidobacterium adolescentis SD-BA5-IT
  • Limosilactobacillus reuteri SD-LRE2-IT

#5 Microbiota-accessible polyphenolic precursors

Another key ingredient in this supplement is 400mg of Indian pomegranate (>40% polyphenolic + phenolic bioactive).

Other Ingredients: Seed DS-01 Daily Synbiotic also contains organic rice fiber, organic rice extract blend, and the stomach acid-resistant vegan outer (chlorophyllin) and inner capsules (containing hypromellose, fermented gellan gum, and water).

A Word From MD

Expert image border HR_author_photo_Edna
Edna Skopljak, MD
Medical advisor for Health Reporter

Probiotic supplements are a great way to give your gut health a kick, which, in turn, can improve your general health. Over time, you might experience better digestion, stronger immunity, and fewer symptoms from digestive ailments like irritable bowel syndrome.

As well as supplementation, you can fit probiotics into your diet by eating fermented foods like sourdough bread, kefir, and yogurt. You can also build healthy habits that keep your GI tract functioning well, like prioritizing dietary fiber, drinking enough water, and exercising regularly.

There is always the potential for side effects when you begin taking probiotics. So, my advice for you is to talk to your doctor beforehand to make sure you choose a product that suits your needs.

Benefits of Seed Probiotics

Primarily, the Seed Probiotic supplement supports the digestive system because of the ingredients it contains. I know from my professional experience that some of the strains that the digestive health probiotic blend has (especially the Bifidobacterium group) are beneficial for your gut health.

Let me explain the potential benefits that this probiotic supplement can offer.

#1 Supports gut health

The Seed formula is packed with probiotics that target the gut microbiome. These beneficial bacteria support the digestive process by promoting regularity, reducing bloating, and hydrating the stool for easier bowel movements.

It also works to restore and maintain the gut barrier – an environment that helps regulate the immune system, allows the body to absorb essential nutrients, and prevents the travel of harmful microorganisms. This is highly important, as a dysfunctional intestinal barrier is associated with several diseases and disorders.

#2 Promotes healthy skin

As I stated above in the “ingredients” section, the formula of this supplement contains a dermatological health probiotic blend, and it comes with strain-specific benefits for your skin.

For instance, it contains Bifidobacterium, which is one of the most popular probiotics for reducing skin inflammation. Additionally, it can also play a role in treating atopic dermatitis and preventing allergic contact dermatitis.

#3 May improve mental health

The Seed DS-01 Daily Synbiotic supplement can improve your mental well-being by improving gut function. The gut-brain axis is a communication system that connects the enteric and central nervous systems, meaning there is a link between the brain and the gut.

What I mean is that your gut has the power to influence your mood and cognitive processes. In other words, a happy gut from probiotic intake can potentially improve mental wellness and help alleviate depression symptoms.

#4 Improves immunity

A large proportion (70%) of your immune system is in your gastrointestinal tract. Therefore, probiotics can boost your immunity by improving your gut health. They keep your intestinal barrier strong to fight off pathogens and prevent harmful substances from entering and causing illness.

#5 Can help with weight management

Certain probiotic supplements can support weight loss by improving nutrient absorption. The Seed DS-01 supplement has strains, such as Bifidobacterium and Lactiplantibacillus groups, that can improve micronutrient synthesis.

An adequate supply of nutrients gives your body energy, ensures you burn calories effectively, and keeps you functioning at your best, which can indirectly improve weight management.

Cons and Side Effects of Seed Probiotics

Just like almost all other supplements, Seed DS-01 also has its own set of downsides. I believe that one should know both the pros and cons of a product before ordering it.

So, let me explain the drawbacks of this supplement.

#1 Temporary adjustment period

Seed probiotics appear to be safe for most people. However, you can experience some side effects after adding a supplement to your regimen, as this has happened with some of my patients.

Fortunately, these symptoms are usually temporary and occur as good bacteria alter your gut flora. The most common symptoms include excess gas production and bloating. But in rare cases, it’s possible to experience constipation and even diarrhea.

#2 Expensive

I have to state that Seed DS-01 is not the most affordable supplement that you can buy. While it’s also not the most expensive one, it’s still pretty costly. A single-day dose of this supplement will cost you $1.66, which might not be something that you would want to pay for a supplement.

It’s also important to note that you need to commit to a monthly subscription if you want to try this product. It means that you’ll need to pay for an entire month, which might not be suitable for people on a very tight budget.

What Do Online Reviews Say About Seed Probiotics?

Before I started examining the Seed DS-01 supplement, I read many online reviews about this product to find out what other people have to say. I have a habit of following this practice because it helps me determine if a product is worth my time and money.

Here’s what only reviews say about this supplement.

What Do Online Reviews Say About Seed Probiotics

Erin is a satisfied customer who experienced good results after taking this supplement, and I’m happy for them.

What Do Online Reviews Say About Seed Probiotics?

The review of this user clearly suggests that Seed DS-01, just like most other probiotics, takes some time to act. While some people can start noticing results within a few days, it’s not always the case.

What Do Online Reviews Say About Seed Probiotics?

Sadly, Merissa didn’t find the Seed DS-01 supplement useful. As I mentioned earlier, it’s possible not to experience any benefits after taking a supplement. If the same happens to you, I recommend you try alternative options.

How Much Do Seed Probiotics Cost?

A single container of Seed DS-01 supplement, which will last you a month, costs $49.99.

While the package contains a travel vial, and everything you receive is recyclable/compostable, which is nice, the price tag still isn’t very affordable. Therefore, it might not be the best option for you if you’re on a budget.

Seed Probiotics vs. Alternatives

Seed is one of the most popular brands offering probiotics, but it’s not the only player out there. There are many other options available that you can consider, including the following.

Comparison Winner: Bioma
Pendulum Probiotics
Biotics 8

Reduces cravings

Stops bloating Increases energy levels

Prevents digestive discomfort, including constipation and diarrhea

Promotes lightness in the gut Improves focus Vegan-friendly



Offers a range of products for different needs

Probiotic strains are grown and tested in their facility

Partnered with leading healthcare brands

Vegetarian-friendly capsules

Dairy, soy, and gluten-free

All-natural ingredients with no preservatives

Supports gut immune function

Boosts skin health

Reduces bloating

No need to refrigerate

Shelf-stable formula


Free from allergens

No preservatives

Unique delivery system

Sustainable refills

Free US shipping


May cause mild side effects, like stomach upset

Pricy subscription plan

Relatively expensive product

Some ingredients aren’t clinically proven to work

Quite expensive

Only formulated for men

Expensive for a 30-day supply compared to other probiotic brands

Must commit to a monthly subscription

Some users report side effects

Not suitable for those under the age of 18


Where to buy Seed probiotics?

You can purchase a 30-day supply (60 capsules) of Seed’s Daily Synbiotic from the official Seed website. The product is available to buy on a subscription basis only for $49.99 per month.
Visit the official website to order the Seed probiotic here.

When to take Seed probiotics?

According to the official Seed website, adults can take 2 capsules simultaneously daily. The makers advise taking the capsules on an empty stomach to minimize exposure to digestive enzymes and bile salts. However, you can still take them with food if you prefer.

Is the Seed probiotic good?

Many Seed customers have acquired health benefits from using the probiotic formula. These dietary supplements contain 24 probiotic strains to support skin health, digestive function, cardiovascular health, gut immune function, and more.

Is the Seed probiotic FDA-approved?

No, the Seed probiotic is not approved by the FDA (Food and Drug Administration). This is because the FDA doesn’t regulate dietary supplements.

Who is Seed for?

Seed Daily Synbiotic is made for people over the age of 18. It’s primarily designed for gastrointestinal support, and people with issues like bloating, irregularity in the bathroom, constipation, and other common gastrointestinal woes will find it most useful.

How I Tested

To review a product thoroughly, I examine its overall quality, effectiveness, cost, and brand reputation. So, read on to learn more about these contributing factors to determine if the Seed DS-01 supplement is worth your money.

Quality 8/10

Quality is one of the most important factors to consider while choosing a dietary supplement because it’ll go inside your body. Luckily, Seed follows high standards when it comes to the quality of ingredients, manufacturing, and packaging.

Additionally, almost all the ingredients it contains are clinically studied and have strain-specific benefits for the human body.

Effectiveness 8/10

There are many positive Seed probiotic reviews from happy customers who find the supplement effective. It comes with a prebiotic outer capsule that keeps the inner probiotic one intact until it reaches the gut, allowing it to work effectively.

The company claims that many people can start noticing results within 24 to 48 hours. While it can be true in some cases, you can expect it to take a few weeks or even months to take action. That’s because the time a dietary supplement takes to work usually varies from person to person.

Price 6/10

As mentioned already, Seed probiotics supplement is pretty expensive. Its monthly supply is costlier than other popular probiotics available in the market. $49.99 per month is more than some people would be willing to pay for supplements, especially those who want something for long-term use.

Brand reputation 8/10

Seed probiotics are made by Seed Health, which is a microbial sciences company specializing in microbes to “improve human and planetary health.” It’s a well-reputed company that focuses on science-backed research and consists of a team of professionals, including scientists and physicians.

Another important factor that speaks for the company’s reputation is the videos of this product being advertised by YouTubers and social media influencers. Most of the videos (at least what I’ve seen) have positive things to say about the supplement and the company.

Seed Probiotics: The Final Verdict

After carefully reviewing the ingredients, I can definitely say that Seed DS-01 Daily Synbiotic is a high-quality probiotic supplement as it offers a unique capsule delivery system backed by clinical research. If you’re willing to commit to the monthly subscription cost, adding it to your regimen could help beat digestive issues and return your gut to good health.

Like any supplement, you should take Seed in conjunction with a balanced diet. It means you shouldn’t rely solely on this product to turn your health around single-handedly.

Lastly, if you’re concerned about the price (or any other thing) of Seed DS-01 Daily Synbiotic, consider looking at other popular probiotics. It’ll help you compare different products and go with the one that suits you the best.

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Dr. Donika Vata
Written by Donika Vata, MD
Fact checked by Edna Skopljak, MD
Last update: September 20, 2023
12 min read 1000 Views 3 Reviews
3 Reviews
  1. user
    20 Jul, 2023 at 8:21 pm
    7/10 quite expensive

    my friend tried it, but for me it’s quite expensive. but she was happy about seed

    reply reply reply
  2. user
    Patrick John
    24 Jul, 2023 at 6:25 pm
    8/10 Not bad

    Not bad. I’ve been drinking Seed for 2 months now. Less constipated, my gut feels lighter.

    reply reply reply
  3. user
    27 Jul, 2023 at 1:56 pm
    10/10 AMAZING!

    best probiotics I’ve tried! amazing!!

    reply reply reply

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