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Home arrow Beauty arrow Skin arrow Best Anti-Aging Serum: 14 Options to Hack Aging

Best Anti-Aging Serum: 14 Options to Hack Aging

HR_author_photo_Rosmy
Written by Rosmy Barrios, MD
HR_author_photo_Edna
Fact checked by Edna Skopljak, MD
Last update: September 25, 2023
10 min read 743 Views 0 Reviews
clock 10 eye 743 comments 0

Discover 14 of the best anti-aging serums to achieve ageless beauty.

Best anti aging serum

How do we vet brands and products? Learn more.

Serums are often called a central part of any skincare routine, even more so as skin matures. 

Anti-aging serums are full of active ingredients and help address the signs of aging. If you’re dealing with wrinkles, fine lines, age spots, pigmentation, dryness, and uneven skin tone, these formulas can deliver assistance to combat or at least minimize these signs.

Browse our round-up of the best anti-aging serums to buy now.

Top 3 Anti-Aging Serums

#1 Best overall star
Skinceuticals logo
4.6
stars
  • Neutralizes free radicals
  • Reduces the appearance of fine lines and wrinkles
  • Increases skin’s firmness and promotes radiant skin
Visit Peter Thomas Roth
Visit SkinCeuticals
#2
Peter Thomas Roth logo
4.4
stars
  • Reduces the visibility of fine lines and wrinkles
  • Evens skin tone and texture
  • It may make the skin appear younger-looking
Visit Peter Thomas Roth
Visit Peter Thomas Roth
#3
Dr. Dennis Gross logo
4.3
stars
  • Diminishes fine lines and wrinkles
  • More even skin tone
  • Refines skin texture
Visit Peter Thomas Roth
Visit Dr. Dennis Gross

14 Best Anti-Aging Serums Right Now

Everybody’s skin ages, but that doesn’t mean you can’t intervene and slow the process or diminish the appearance of tell-tale signs. The plentiful list below comprises the best picks for addressing mature skin concerns, covering all budgets and skin types.

#1 SkinCeuticals C E Ferulic Acid – Best overall

Skinceuticals logo
Our rating:
4.6
stars
  • Protects skin from free radicals
  • Reduces the appearance of fine lines and wrinkles
  • Increases skin’s firmness
Learn More

This product comes highly rated, gracing the lists of many top-pick serums. 

SkinCeuticals C E Ferulic serum is a potent vitamin C serum with 15% L-ascorbic acid (pure vitamin C). With the addition of vitamin E, this antioxidant combination protects skin from free radical damage generated by UVA and UVB rays, ozone pollution, and diesel engine exhaust fumes.

In addition to its protective benefits, it brightens the skin, increases firmness, and improves the appearance of fine lines and wrinkles. Ultimately, it’s a multi-talent that keeps skin looking radiant and youthful while working on a deeper level to keep skin healthy.

Pros
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    Brightens and plumps skin
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    Offers advanced environmental protection
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    Ideal for normal, dry, and sensitive skin types
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    Paraben-free
Cons
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    It smells bad
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    It’s not cruelty-free

#2 Peter Thomas Roth Peptide 21 Wrinkle Resist Serum – Best for moisture retention

Peter Thomas Roth logo
Our rating:
4.4
stars
  • Reduces the visibility of fine lines and wrinkles
  • Evens skin tone and texture
  • It may make the skin appear younger-looking
Learn More

If you’re looking for a serum to counter deep wrinkles, this wrinkle-fighting formula from Peter Thomas Roth is designed to do just that. The blend of peptides, neuropeptides, and gamma proteins targets the face and neck to produce skin that appears noticeably younger.

The 73% peptide and neuropeptide complex helps smooth fine lines and wrinkles. Gamma proteins boost elasticity and radiance while improving uneven tone and skin texture. 

It has hyaluronic acid, a humectant that hydrates the skin and locks in much-needed moisture. As well as combating dry skin, hyaluronic acid is beneficial for acne-prone skin in some people.

Pros
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    Hyaluronic acid boosts skin’s hydration levels
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    Suitable for every skin type, particularly dry skin
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    Restores elasticity to the skin
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    May brighten skin and alleviate dullness
Cons
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    Little sticky
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    High price tag ($125.00 for 30ml)

#3 Dr. Dennis Gross Advanced Retinol + Ferulic Overnight Wrinkle Treatment – Best with niacinamide

Dr. Dennis Gross logo
Our rating:
4.3
stars
  • Diminishes fine lines and wrinkles
  • More even skin tone
  • Refines skin texture
Learn More

This anti-wrinkle product’s rich, buttery texture doubles as a hydrating serum for dry to normal skin types and a moisturizer for oily skin. It is an overnight treatment that repairs skin while you sleep, allowing you to wake up with a visibly firmer complexion.

Retinol, a vitamin A derivative, is considered an effective substance for slowing the aging process, making this retinol treatment appealing. Retinol penetrates the dermis and strengthens the protective function of the epidermis (the outermost layer of the skin).

It also exfoliates and boosts collagen production, helping to correct fine lines and wrinkles caused by natural collagen decline.

It has ferulic acid, an antioxidant compound known to reduce signs of photoaging, with moisture-inducing and redness-reducing qualities.

Pros
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    May boost radiance
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    Smoothes and softens skin
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    Strengthens skin barrier
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    Lasts longer since you only use it at night
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    Airless pump
Cons
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    May cause irritation to some people
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    Strong smell

#4 Drunk Elephant T.L.C. Framboos™ Glycolic Night Serum – Best for exfoliation

drunk elephant logo
Our rating:
4.2
stars
  • Resurfaces dull and tired skin
  • Enhances luminosity
  • Exfoliates the skin
Learn More

The Glycolic Night Serum is an AHA/BHA gel formulated with glycolic, tartaric, lactic, citric, and salicylic acid. It ultimately serves to gently exfoliate and eradicate dull and tired-looking skin to reveal a brighter, more luminous complexion overnight.

This night serum minimizes the appearance of pores, fine lines, and wrinkles while improving skin tone and texture. Other ingredients like raspberry fruit extract and horse chestnut seed extract soothe skin and defend against harmful free radicals.

The philosophy behind Drunk Elephant is to skip the 6 potentially troublesome ingredients for the skin. These include essential oils, alcohol, silicones, chemical sunscreens, SLS, fragrances, and dyes.

Pros
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    Improves skin tone and texture
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    May help with acne
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    Contains soothing plant extracts
  • checkmark
    Affordable
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    Long-lasting
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    Cruelty-free and vegan
Cons
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    Glycolic acid might be too harsh for sensitive skin
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    It can be drying

#5 Murad Retinol Youth Renewal Serum – Best for skin plumping effect

murad logo
Our rating:
4.2
stars
  • Helps reduce visible signs of aging
  • Combats dullness and uneven tone
  • Promotes plump skin
Learn More

As the name suggests, this anti-aging retinol serum focuses on restoring youthful skin. It uses three retinol technologies – a fast-acting retinoid, a time-release retinol, and a retinol booster to quickly improve 5 key signs of aging in as little as 4 weeks. 

Retinol can be drying at first, but Murad adds hyaluronic acid to combat this issue and ensure adequate hydration. Hyaluronic acid is also great for plumping the skin. Swertia flower extract helps the skin build resilience to enhance protection while clearing imperfections.

Pros
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    Suitable for sensitive skin
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    Free from parabens, sulfates, phthalates, and gluten
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    No animal-derived ingredients
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    Subscribe and save option
Cons
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    Some people may experience sensitivity
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    It’s fragranced

#6 The Ordinary “Buffet” + Copper Peptides 1% – Best with copper peptides

the ordinary logo
Our rating:
4.2
stars
  • Improves the appearance of fine and dynamic lines
  • Boosts elasticity
  • Supports smoothness and firmness
Learn More

The Ordinary is one of the best brands when you want something powerful without the hefty price tag. “Buffet” + Copper Peptides 1% is an intense advanced serum offering age support. It targets multiple signs of aging, including crow’s feet which many people battle daily.

The formula is enriched with peptides, amino acids, and multiple hyaluronic acids. Collagen and elastin production slow with age, but “Buffet” supports your skin’s overall elasticity to help plump, smooth, and firm the skin.

Direct copper peptides specifically target signs of aging associated with free radical damage, making way for a healthier-looking appearance. At just $30.90, this anti-aging serum is well worth a try.

Pros
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    Helps skin look more radiant
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    Targets various signs of aging
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    A little goes a long way
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    Budget-friendly
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    Vegan and cruelty-free
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    Free from alcohol, oils, silicones, and allergens
Cons
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    It can feel sticky after application
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    Some customers report only minimal improvements

#7 Tula Deep Wrinkle Serum – Best for skin smoothing and plumping 

tula logotype
Our rating:
4.1
stars
  • Improves the look of wrinkles
  • Target signs of premature aging
  • Improves elasticity to leave skin looking more firm and smooth
Learn More

You can apply this milky anti-aging serum in the morning and at night to improve the look of stubborn wrinkles. It uses a botanical retinol alternative, peptides, prebiotics, and probiotic extracts to achieve various goals, including nourishing, brightening, firming, and hydrating the skin.

Eye, neck, and lip wrinkles are common with aging skin, but boosting the skin’s elasticity can help to smooth away these lines. Reviews suggest this might be the best anti-aging serum for plumping and minimizing deep wrinkles without retinol.

Pros
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    Makes skin brighter
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    Softens skin
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    Contains prebiotics and probiotics to support the skin’s microbiome
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    Suitable for all skin types, including blemish-prone skin
Cons
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    Thicker consistency
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    Seems to work well for some but not others

#8 Shani Darden Retinol Reform – Best for quick results

shani darden logo
Our rating:
4.1
stars
  • Restores skin’s firmness
  • Helps with fine lines
Visit Shani Darden Retinol Reform

The encapsulated retinol in this reforming potion releases the retinol more slowly to prevent the traditionally irritating effects of ordinary retinol. It works hard overnight to reduce the signs of aging, allowing you to wake up with firmer, younger-looking skin.

The lactic acid gently exfoliates, creating a smoother, more even surface on the face with quick-acting brightening results. It can also help to maintain the integrity of the epidermal barrier and provide moisturizing benefits.

Pros
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    Better skin tone
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    Fewer blemishes
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    Cruelty-free
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    Vegan
Cons
  • checkmark
    Problems with the pump
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    Too intense for some people

#9 Current State Retinol + Marula Renewing Serum – Best for tired and dull skin

CurrentState logo
Our rating:
4.0
stars
  • Brightens and freshens tired-looking skin
  • Boosts radiance
  • Refines the appearance of fine lines and wrinkles
Learn More

This is a serum that, according to the makers, dials back the signs of skin damage for an ageless appearance. Due to its renewing effects from a combination of encapsulated retinol and kojic acid, it can help to fade fine lines and dark spots.

It also has aloe, marula, and jojoba oils to nourish, protect, and balance the retinol to prevent potential irritation. Apply it generously to help counter face, neck, and chest wrinkles.

Pros
  • checkmark
    Encourages bouncier skin
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    Replenishes the skin’s moisture barrier
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    Contains moisturizing oils
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    Less expensive than most serums
Cons
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    The pump dispenses too much product
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    It feels more like a lotion than a serum

#10 Saint Jane Superflower Detox Serum – Best for textured skin

saint jane logo
Our rating:
4.0
stars
  • Purifies pores
  • Increases firmness
  • Shields skin from environmental stressors
Learn More

If you’re after a super detoxifying formula, the Saint Jane Superflower Detox Serum offers a ton of benefits. From hydrating the skin and clearing the pores to eradicating rough patches, you can expect a more balanced complexion after use.

Described as a nourishing green juice for your skin, it’s packed with moisturizing rose, soothing chamomile, and neroli essential oil to smooth fine lines.

Pros
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    Restores radiance
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    Good for moisture retention
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    Luxury packaging
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    Heavenly smell
Cons
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    Contains oils and fragrances
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    Might be irritating to sensitive skin

#11 Innisfree Retinol Cica Moisture Recovery Serum – Best for acne-prone skin

innisfree logo
Our rating:
3.9
stars
  • Boosts elasticity and firmness
  • Promotes an all-round clearer complexion
  • Improves the look of visible imperfections
Learn More

This gentle daily retinol serum works on the skin’s elasticity and firmness for a clearer complexion. It not only targets wrinkles and rough texture but also helps improve acne-prone skin.

It contains salicylic acid, a beta-hydroxy acid, and a known acne treatment that decreases skin lipids and calms inflammation. It also features hyaluronic acid to relieve dryness and excess sebum production – two common acne triggers.

Meanwhile, antioxidants from vitamin E fight free radical damage induced by environmental factors.

Pros
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    Decreases the number of dead skin cells
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    Softens skin
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    Minimizes pores
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    Offers a no-waste recycling program
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    Lightweight
Cons
  • checkmark
    Some find it drying
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    You won’t see significant improvements

#12 L’Oreal Paris 1.5% Pure Hyaluronic Acid Serum – Best if you’re on a budget

loreal paris logo
Our rating:
3.8
stars
  • Fully hydrates the skin
  • Produces visibly bouncy and glowy skin
  • Reduces wrinkles over time
Learn More

The 1.5% Pure Hyaluronic Acid Serum is a must-have for hydration. It contains a high concentration of hyaluronic acid, one of the best anti-aging ingredients for skin moisture, as it has a unique capacity for holding water. Hydration is essential for mature skin since it naturally loses moisture through daily injury and natural aging.

The hydrating properties contribute to plumper skin and aid wrinkle reduction. You can expect a dewy glow following the application. It’s best for dry, sensitive, mature, and sagging skin.

Pros
  • checkmark
    Protects the skin barrier
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    Fast-absorbing
  • checkmark
    Suitable for everyone
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    Paraben, dye, and fragrance-free
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    A little goes a long way
Cons
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    Won’t give immediate results
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    May cause an unpleasant tingling sensation

#13 Kiehl’s Retinol Skin-Renewing Serum – Best for retinol beginners

kiehls logo
Our rating:
3.8
stars
  • Wrinkle reduction
  • Corrects tone and texture
Learn More

Another retinol anti-aging serum, this best-seller from Kiehl’s, is made for daily use to minimize wrinkles, balance skin tone, firm skin, and improve texture. Pure retinol, ceramides, and peptides stimulate cell turnover to release fresh skin that looks more youthful.

It’s free from irritating ingredients, making it a good choice for sensitive skin. You can apply it carefully under the eyes and in the crow’s feet area, avoiding the eyes and lids. The brand recommends using it alongside other targeted serums for dark spots, plumping effects, and more.

Pros
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    Accelerates skin cell turnover
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    Promotes more comfortable skin
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    Improves skin firmness
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    Suitable for sensitive skin type
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    Minimal discomfort to prevent redness, dryness, and peeling
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    Paraben-free
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    Fragrance-free
Cons
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    May cause breakouts
  • checkmark
    Some people report dryness

#14 RoC Retinol Correxion Deep Wrinkle Serum – Best for improving stubborn fine lines

roc logo
Our rating:
3.7
stars
  • Improves the visibility of deep-set wrinkles
  • Smoothes and firms skin on the face and neck
Learn More

This wrinkle serum with retinol helps to reduce the appearance of deep-set wrinkles on the face and neck, promoting smoother-looking skin in just 4 weeks. It accelerates the body’s natural removal of dead skin cells to reveal new skin cells for more vibrant and healthy skin.

Its benefits come from retinol, which reduces fine lines and wrinkles by boosting collagen production. Users report less noticeable crow’s feet, smaller-looking pores, and skin-tightening effects that result in plumper skin. It has a silky texture without leaving the skin feeling oily.

Pros
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    Antioxidant effects from vitamin C
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    Improves the appearance of pores
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    Absorbs quickly
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    Hydrating
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    Budget-friendly
Cons
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    It can take a few weeks to see the results
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    Overwhelming fragrance

Comparison Table

4.6
stars
4.4
stars
4.3
stars
4.2
stars
4.2
stars
4.2
stars
4.1
stars
4.1
stars
4.0
stars
4.0
stars
3.9
stars
3.8
stars
3.8
stars
3.7
stars
Brand
SkinCeuticals C E Ferulic Acid 
Peter Thomas Roth Peptide 21 Wrinkle Resist Serum 
Dr. Dennis Gross Advanced Retinol + Ferulic Overnight Wrinkle Treatment
Drunk Elephant T.L.C. Framboos™ Glycolic Night Serum
Murad Retinol Youth Renewal Serum
The Ordinary “Buffet” + Copper Peptides 1%
Tula Deep Wrinkle Serum
Shani Darden Retinol Reform
Current State Retinol + Marula Renewing Serum
Saint Jane Superflower Detox Serum
Innisfree Retinol Cica Moisture Recovery Serum
L’Oreal Paris 1.5% Pure Hyaluronic Acid Serum
Kiehl’s Retinol Skin-Renewing Serum
RoC Retinol Correxion Deep Wrinkle Serum
Pros

Brightens skin

Plumps skin

Offers advanced environmental protection

Ideal for normal, dry, and sensitive skin types

Paraben-free

Hyaluronic acid boosts skin’s hydration levels

Suitable for every skin type, particularly dry skin

Encourages firm skin

May brighten skin and alleviate dullness

It may boost radiance

Smoothes and softens skin

Contains niacinamide to aid skin hydration and strengthen the skin barrier

Lasts longer since you only use it at night

Airless pump to stop waste

Improves skin tone and texture

Improves the appearance of pores, wrinkles, and fine lines

May help with acne

Contains soothing plant extracts to prevent irritation

Slightly more affordable

Long-lasting

Cruelty-free and vegan

Pretty packaging

Suitable for sensitive skin

Free from parabens, sulfates, phthalates, and gluten

No animal-derived ingredients

Subscribe and save option

Helps skin look more radiant

Targets various signs of aging

Budget-friendly

Vegan and cruelty-free

Free from alcohol, oils, silicones, and allergens

Adds bounce back to the skin

Softens skin

Contains prebiotics and probiotics to support the skin’s microbiome

Suitable for all skin types, including blemish-prone skin

Better skin tone

Fewer blemishes

Cruelty-free

Vegan

Encourages bouncier skin

Replenishes the skin’s moisture barrier

Contains moisturizing oils

Less expensive than most serums

Restores radiance Good for moisture retention

Luxury packaging

Heavenly smell

Decreases the number of dead skin cells Softens skin

Minimizes pores

Offers a no-waste recycling program

Protects the skin barrier

Fast-absorbing

Suitable for everyone

Paraben, dye, and fragrance-free

A little goes a long way

Accelerates skin cell turnover

Promotes more comfortable skin

Improves skin firmness

Suitable for sensitive skin type

Minimal discomfort to prevent redness, dryness, and peeling

Paraben-free

Fragrance-free

Antioxidant effects from vitamin C

Improves the appearance of pores

Absorbs quickly

Hydrating

Budget-friendly

Cons

Unpleasant smell

It’s not cruelty-free

No indication of the ingredient amounts

High price tag

May cause irritation in some people

Strong metallic smell

Glycolic acid might be too harsh for sensitive skin

It can be drying

Some people may experience sensitivity

It doesn’t specify the quantity of retinol

It can feel sticky after application

Some customers report only minimal improvements

Thicker consistency

Seems to work well for some but not others

Problems with the pump

Too strong for some people

The pump dispenses too much product

Feels more like a lotion than a serum

Contains oils and fragrances

Might be too much for sensitive skin

Some find it drying

May cause an unpleasant tingling sensation

May cause breakouts

Some people report dryness

It can take a few weeks to see the results

Overwhelming fragrance

How We Picked the Products

To compile our list, we rated each formula based on its quality, how well it works, the cost, and the brand’s reputation. This helps us to develop a clear picture of the best skincare products available right now, allowing us to recommend a select few.

Here’s a little more detail:

Quality

Although our picks include a variety of price points, we have included only high-quality serums. They are well-formulated with a blend of safe and active ingredients and are made without rubbish or unnecessary ingredients that don’t deliver.

Price

The price of a product is a pivotal part of the shopping process. It determines whether or not a product is sustainable to use long-term or if it’s only accessible as a treat. Ideally, a serum should be affordable and suitable for consistent use. The serums in this review range in price to suit a variety of budgets, as everyone can benefit from using an anti-aging serum.

Brand reputation

If you’re going to trust a product to work magic on your skin, you must trust the brand behind it. We picked serums from reputable brands in the skincare industry to ensure their safety and reliability and meet customer expectations.

Effectiveness

We put these serums to the test by studying their formulas and assessing the function of their anti-aging ingredients. We understand that anti-aging products are no good if they don’t contain key ingredients that actually work to support and protect the skin from signs of aging.

FAQs

Do anti-aging serums work?

Anti-aging serums can work, but select one with some key ingredients. The current science suggests that retinol, hyaluronic acid, glycolic acid, fatty acids, and vitamins C and E are among the most effective anti-aging ingredients for delivering results.

What consistency does serum have?

Serum is thin and watery or gel-like in consistency. Most serums absorb quickly and don’t leave a residue or unpleasant layer on the skin’s surface. A potent and effective serum will penetrate deep into the skin’s layers. You should apply it before your daily moisturizer.

Is serum oily or watery?

Most serums are water-based and are clear, thin, and watery. They are lighter than moisturizers and should be applied and allowed to absorb before using these products. Serums can be oily if they contain oil-based ingredients, such as carrier oils.

What should I look for when buying anti-aging serum?

Assessing the ingredients list is crucial when shopping around for an anti-aging serum. It should contain proven anti-aging ingredients to address your skin concerns. Consider a moisturizing serum if you are trying to counter dryness.

A Word From a Dermatologist

Aging is a complex process that scientists are still investigating. We know our actions throughout our lives influence health as we age. This is especially true for aging skin, as several factors significantly impact how the skin looks over time.

While aging is inevitable, you can delay or reduce the effects of aging on your skin. An effective skincare regimen is the first place to start. This is one way to ensure your delicate skin gets enough care, moisture, and protection from factors that accelerate aging.

Anti-aging serums, moisturizers, and sunscreens are pivotal to protecting the skin. Hydrating yourself with optimal water intake and eating anti-aging foods like vegetables, herbs, and spices will fuel your body with antioxidants and other nutrients to maintain healthy skin.

Conclusion

Depending on your goals, these serums could be a winner for your anti-aging skincare regimen. For a supreme serum that handles a range of jobs, we prefer SkinCeuticals C E Ferulic. It improves the appearance of your skin while keeping it safe from oxidative damage, improving existing signs of aging and preventing future ones.

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum and Dr. Dennis Gross Advanced Retinol + Ferulic Overnight Wrinkle Treatment follow closely behind. These serums work hard to tackle wrinkles and leave your skin looking and feeling flawless.

Written by Rosmy Barrios, MD
Dr. Rosmy Barrios, MD, is a medical advisor for the Health Reporter, the head of the anti-aging department, and a regenerative medicine specialist in several medical institutions with years of experience in aesthetic medicine and cosmetology.
The article was fact checked by Edna Skopljak, MD
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HR_author_photo_Rosmy
Written by Rosmy Barrios, MD
HR_author_photo_Edna
Fact checked by Edna Skopljak, MD
Last update: September 25, 2023
10 min read 743 Views 0 Reviews
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